Monday, November 17, 2014

What is the structure of DNA?

How can we make a model of DNA to show it's structure?
How does DNA replicate?
What does the processes of transcription look like?

Using the materials on the table, create one large polymer of A, T, G, & C (about 100 beads in length).  This is one side of the DNA molecule.  What would the other side look like?  Again, using the materials on the table, create the complementary side of DNA, how might you connect the sides? (take a picture when both sides are together, make sure to label the ends with 5' and 3')

How does the structure of DNA make it a stable molecule?
Can you twist the molecule to show it's helical nature?
Where might the histone proteins be located? (what could you use to model them?) Another picture opportunity -- coiled and histone proteins added
How might the location of the histone proteins affect gene expression?

How will the DNA replicate?  Why might it not start at one end and go to the other? Again, using the materials provided, work with your model to show DNA replication. Picture time again, should be able to see Okazaki fragments (and they need to be explained in your submission) :)

Using your original model (or one of the newly replicated strands), show how TRANSCRIPTION works.  (remember to use a different color for the uracil). Where is your promoter region? How does the process stop? Another picture of this process, please :)

Crash Course Biology (DNA structure and replication)
DNA learning center: How DNA is assembled
Crash Course Biology (DNA, Hot Pockets, & the longest word ever)

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