Read the original article "A Structure for Dexoxyribonucleic Acid". Mark up the text, this is a difficult journal article to get through. Stop as you are reading. Talk with another classmate. Use these questions to help get to the meaning of the article.
Click here for information about Linus Pauling's hypothesis about the structure of DNA
1. Describe the structure of DNA monomers by using citations from the article. How is the structure arranged, that is, which of the “parts” are on the outside? Which ones are on the inside of the molecule? Cite the article.
2. How did Linus Pauling’s model differ from Watson and Crick’s model for DNA? Explain in detail.
3. What type of bond holds the bases together? Cite the article. From what we have talked about this year regarding this bond, how might this bond affect the overall stability of the DNA molecule?
4. In the eighth paragraph, a very important observation is made about base pairing. What is the significance of how bases pair up?
5. Reread the last half of the article. Based on what Watson and Crick say, try to hypothesize what their “possible copying mechanism” might be. Use clues from the article in your explanation.
Watch "The Secret of Photo 51" about Rosalind Franklin's research and contribution to the discovery of the structure and function of DNA.
Your summary can be done in pairs and will be submitted to Canvas.
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